5/15/2025
Last update
5/15/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 8 Reviews
8.4
Supplement Facts
Serving Size: 4 capsules
Amount Per Serving
%DV
Vitamin D (as ergocalciferol)
10 mcg (400 I.U.)
50%
Calcium (as calcium hydroxyapatite, calcium citrate, calcium aspartate)†
1,000 mg
77%
Phosphorus (as calcium hydroxyapatite)†
500 mg
40%
Magnesium (as magnesium oxide, magnesium aspartate, magnesium citrate, magnesium taurinate)†
500 mg
119%
Top Medical Research Studies
9
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
Read More
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
7
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
Most Useful Reviews
9
Excellent bone support
4 people found this helpful
COOL FROM COOL) A superb calcium from the Country Life brand, which many adore. An effective 1000mg calcium dosage per serving is in a highly absorbable "blended" form of hydroxyapatite and calcium chelates, ideal for musculoskeletal and joint issues. This form is optimal for strengthening teeth, with magnesium and 400 IU of Vitamin D3 aiding absorption. The large container lasts for two months; recommended intake is one capsule in the latter half of the day before bedtime for better absorption. It excels at maintaining the bone health of the elderly. I highly recommend it - may the power of iHerb be with you!! Yours, Tati.
Read More
9
Bone pain improvement
1 people found this helpful
Every woman should consider vitamins beyond pregnancy. After giving birth, I sought quality calcium and magnesium, and this product met my needs. I no longer experience bone pain; I've noticed significant improvement—give it a try! Plus, it's halal!
Read More
9
Quick bone healing
2 people found this helpful
I initially bought it for my mother, then for my father; what a challenging year it was with their fractures. It works effectively; their bones heal swiftly. My parents also take vitamin D in the morning along with glucosamine. If you find this helpful, please like it.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
- All Researches
9
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
Read More
9
We conducted an insightful study to analyze how combining calcitriol, a form of vitamin D, with bisphosphonates affects bone pain in postmenopausal women suffering from osteoporosis. This quasi-experimental approach allowed us to compare two groups: one treated with calcitriol alone and the other with the combination treatment.
Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.
Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.
Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.
Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.
Read More
8
We investigated the connection between vitamin D levels and the risk of new vertebral fractures in postmenopausal women who had undergone percutaneous vertebral augmentation. Through a retrospective case-control study involving patients aged 50 and older, we analyzed records to categorize participants into groups based on whether they experienced refractures and how serum levels of 25-hydroxyvitamin D (25[OH]D) influenced these outcomes.
Our findings revealed that low levels of serum 25(OH)D are linked to an increased risk of new vertebral fractures in these patients. What's noteworthy is that vitamin D plays a crucial role in maintaining bone health, and adequate levels can help reduce the likelihood of subsequent fractures after surgery. This underscores the potential importance of vitamin D supplementation for patients recovering from vertebral augmentation.
In conclusion, ensuring that patients receive appropriate vitamin D intake might be pivotal in preventing further bone pain and fractures following surgery. By addressing vitamin D deficiency, we could significantly improve bone health outcomes and enhance the quality of life for postmenopausal women recovering from vertebral fractures.
Our findings revealed that low levels of serum 25(OH)D are linked to an increased risk of new vertebral fractures in these patients. What's noteworthy is that vitamin D plays a crucial role in maintaining bone health, and adequate levels can help reduce the likelihood of subsequent fractures after surgery. This underscores the potential importance of vitamin D supplementation for patients recovering from vertebral augmentation.
In conclusion, ensuring that patients receive appropriate vitamin D intake might be pivotal in preventing further bone pain and fractures following surgery. By addressing vitamin D deficiency, we could significantly improve bone health outcomes and enhance the quality of life for postmenopausal women recovering from vertebral fractures.
Read More
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
Read More
7
Promising drug delivery for osteoporosis
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Excellent bone support
4 people found this helpful
COOL FROM COOL) A superb calcium from the Country Life brand, which many adore. An effective 1000mg calcium dosage per serving is in a highly absorbable "blended" form of hydroxyapatite and calcium chelates, ideal for musculoskeletal and joint issues. This form is optimal for strengthening teeth, with magnesium and 400 IU of Vitamin D3 aiding absorption. The large container lasts for two months; recommended intake is one capsule in the latter half of the day before bedtime for better absorption. It excels at maintaining the bone health of the elderly. I highly recommend it - may the power of iHerb be with you!! Yours, Tati.
Read More
9
Bone pain improvement
1 people found this helpful
Every woman should consider vitamins beyond pregnancy. After giving birth, I sought quality calcium and magnesium, and this product met my needs. I no longer experience bone pain; I've noticed significant improvement—give it a try! Plus, it's halal!
Read More
9
Quick bone healing
2 people found this helpful
I initially bought it for my mother, then for my father; what a challenging year it was with their fractures. It works effectively; their bones heal swiftly. My parents also take vitamin D in the morning along with glucosamine. If you find this helpful, please like it.
Read More
7.5
Bone health support
I regularly consume this for bone health. Its quality and ingredients are commendable; it's small, easy to take, and effective. I use it as a preventive measure against osteoporosis in older individuals.
Read More
7.5
Good for bone health
Good! A wonderful complex of magnesium and calcium with vitamin D3, which has a positive effect on bone health.
Read More
Frequently Asked Questions
9
Bone pain improvement
1 people found this helpful
Every woman should consider vitamins beyond pregnancy. After giving birth, I sought quality calcium and magnesium, and this product met my needs. I no longer experience bone pain; I've noticed significant improvement—give it a try! Plus, it's halal!
7.5
Improved energy levels
After taking calcium, magnesium, and vitamin D, I felt more energetic and noticed an improvement in my bone health. I recommend this complex to anyone who cares about bone health and overall well-being.
7.5
Bone health support
I regularly consume this for bone health. Its quality and ingredients are commendable; it's small, easy to take, and effective. I use it as a preventive measure against osteoporosis in older individuals.
9
Quick bone healing
2 people found this helpful
I initially bought it for my mother, then for my father; what a challenging year it was with their fractures. It works effectively; their bones heal swiftly. My parents also take vitamin D in the morning along with glucosamine. If you find this helpful, please like it.
8
We investigated the connection between vitamin D levels and the risk of new vertebral fractures in postmenopausal women who had undergone percutaneous vertebral augmentation. Through a retrospective case-control study involving patients aged 50 and older, we analyzed records to categorize participants into groups based on whether they experienced refractures and how serum levels of 25-hydroxyvitamin D (25[OH]D) influenced these outcomes.
Our findings revealed that low levels of serum 25(OH)D are linked to an increased risk of new vertebral fractures in these patients. What's noteworthy is that vitamin D plays a crucial role in maintaining bone health, and adequate levels can help reduce the likelihood of subsequent fractures after surgery. This underscores the potential importance of vitamin D supplementation for patients recovering from vertebral augmentation.
In conclusion, ensuring that patients receive appropriate vitamin D intake might be pivotal in preventing further bone pain and fractures following surgery. By addressing vitamin D deficiency, we could significantly improve bone health outcomes and enhance the quality of life for postmenopausal women recovering from vertebral fractures.
Our findings revealed that low levels of serum 25(OH)D are linked to an increased risk of new vertebral fractures in these patients. What's noteworthy is that vitamin D plays a crucial role in maintaining bone health, and adequate levels can help reduce the likelihood of subsequent fractures after surgery. This underscores the potential importance of vitamin D supplementation for patients recovering from vertebral augmentation.
In conclusion, ensuring that patients receive appropriate vitamin D intake might be pivotal in preventing further bone pain and fractures following surgery. By addressing vitamin D deficiency, we could significantly improve bone health outcomes and enhance the quality of life for postmenopausal women recovering from vertebral fractures.
9
We explored the impact of vitamin D3 levels on bone pain that patients experience after undergoing unicompartmental knee arthroplasty (UKA). The study involved 240 participants who were divided into three groups based on their vitamin D status—some received treatment before surgery, some after, and others had normal levels to begin with.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
By administering vitamin D3 in three doses, we aimed to see if correcting deficiencies could alleviate post-operative bone pain. Throughout the recovery period, we measured pain levels using the visual analog scale at various intervals after the surgery.
Our findings clearly demonstrated that patients who corrected their vitamin D3 deficiency before surgery reported significantly better pain control after the operation compared to those who were treated afterwards or those who started with adequate levels. This highlights the importance of testing and addressing vitamin D status prior to orthopedic procedures, showing that it is a modifiable risk factor affecting recovery.
9
We conducted an insightful study to analyze how combining calcitriol, a form of vitamin D, with bisphosphonates affects bone pain in postmenopausal women suffering from osteoporosis. This quasi-experimental approach allowed us to compare two groups: one treated with calcitriol alone and the other with the combination treatment.
Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.
Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.
Our findings highlighted that adding bisphosphonates to calcitriol significantly alleviated bone pain among the participants. We observed improved evaluations of joint pain through the Visual Analogue Scale/Score, indicating that patients felt much better post-treatment. Furthermore, the combination therapy enhanced the patients' overall daily living capabilities and positively influenced bone metabolism and density.
Overall, our results suggest that calcitriol combined with bisphosphonates is effective in not just relieving pain but also supporting the long-term health of bones in postmenopausal women. This approach may pave the way for improved treatment strategies for osteoporosis in this demographic.
8
We explored the impact of calcium treatment on bone pain in patients who developed osteomalacia, a condition linked to intravenous iron infusions. Our focus was on a group of 13 patients diagnosed with this condition, who experienced low phosphate levels due to excess fibroblast growth factor 23 (iFGF23) after receiving ferric carboxymaltose (FCM) infusions.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
After halting the FCM infusions, these patients were given supportive treatment, which included phosphate, calcium, and active Vitamin D supplementation. We observed improvements in biochemical markers, including increased phosphate levels and reduced pain scores. However, it’s important to note that while calcium was part of the treatment regimen, we could not isolate its specific effects on bone pain from the other supportive measures used.
Ultimately, our findings highlight the importance of monitoring phosphate levels in patients receiving FCM, and stopping these infusions effectively addresses phosphate wasting. Although supportive treatment showed improvements in pain and bone density, the direct impact of calcium on bone pain remains unclear given the combination of treatments involved.
References
- Zhang SB, Yang J, Xu HW, Yi YY, Ren CX, et al. Association Between 25-hydroxyvitamin D Status and New Vertebral Fractures Post Percutaneous Vertebral Augmentation in Patients During Postmenopause: A Retrospective Case-control Study. Pain Physician. 2025;28:E31.
- Rajani AM, Mittal A, Kulkarni VU, Rajani KA, Rajani KA. Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty. Malays Orthop J. 2024;18:7. 10.5704/MOJ.2411.002
- Han K, Wang X. Clinical efficacy and outcomes of calcitriol combined with bisphosphonates in the treatment of postmenopausal osteoporosis: A quasi-experimental study. Medicine (Baltimore). 2024;103:e40171. 10.1097/MD.0000000000040171
- von Brackel FN, Grambeck J, Barvencik F, Amling M, Oheim R. In-depth clinical characterization of intravenous iron infusion-induced hypophosphatemic osteomalacia and its resolution. JBMR Plus. 2024;8:ziae139. 10.1093/jbmrpl/ziae139
- Alsaikhan F, Mahmoud MZ, Suliman M. Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis. Front Bioeng Biotechnol. 2023;11:1153969. 10.3389/fbioe.2023.1153969
- Jakubowska-Pietkiewicz E, Chlebna-Sokół D. New trends in the treatment of osteogenesis imperfecta type III - own experience. Ortop Traumatol Rehabil. 2008;10:593.
- Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129.
